Possible mechanism underlying the effect of Semax on the formation of indomethacin-induced ulcers in rats.

Bulletin of experimental biology and medicine20025 citationsPMID: 12447470

Animal StudySemax

Plain Language Summary

This study explored the mechanism by which Semax prevents indomethacin-induced gastric ulcers in rats. The neuropeptide's gastroprotective effect appears to involve modulation of inflammatory pathways triggered by the NSAID, expanding understanding of Semax's protective properties beyond the nervous system.

Abstract

Intraperitoneal injection of Semax (synthetic analogue of ACTH4-7, MEHFPGP) in a dose of 50 mg/kg produced a protective effect on rats with experimental indomethacin-induced ulcers. Experiments on narcotized rats showed that Semax in the studied dose had no effect on basal blood flow in the stomach, but prevented reduction of blood flow induced by indomethacin. The antiulcer effect of Semax is probably related to improvement of blood flow in the gastric wall disturbed by indomethacin.

Authors

Zhuikova, S E; Sergeev, V I; Samonina, G E; Myasoedov, N F