Effect of Vilon and Epithalon on glucose and glycine absorption in various regions of small intestine in aged rats.

Bulletin of experimental biology and medicine2002PMID: 12420071

Animal StudyEpitalon

Plain Language Summary

Oral administration of Epitalon for one month improved nutrient absorption in the small intestines of aged rats. The peptide enhanced glucose absorption in specific intestinal regions and improved glycine uptake in the proximal intestine, suggesting it can help restore digestive function that declines with age.

Abstract

Vilon (Lys-Glu) and Epithalon (Ala-Glu-Asp-Gly) administered orally for 1 month improved transport characteristics of the small intestine in aged rats. Vilon enhanced passive glucose accumulation in the serous fluid in inverted sac made from the distal region of the small intestine, while Epithalon enhanced this process in the medial region. Vilon stimulated active glucose accumulation in the serous sac of the medial small intestine, Epithalon - in the proximal and distal small intestinal segments. Glycine absorption increased only in the proximal intestinal segment under the effect of Epithalon.

Authors

Khavinson, V Kh; Egorova, V V; Timofeeva, N M; Malinin, V V; Gordova, L A; Gromova, L V