Comparative study of modulatory effects of Semax and primary proline-containing peptides on hemostatic reactions.

Bulletin of experimental biology and medicine20013 citationsPMID: 11687836

Animal StudySemax

Plain Language Summary

This study compared the effects of Semax and primary proline-containing peptides on hemostatic reactions. The modulatory effects on blood coagulation and fibrinolysis differed between the full-length Semax molecule and its component peptide fragments, helping delineate the structural requirements for Semax's vascular effects.

Abstract

Intranasal administration of Semax, peptide Pro-Gly-Pro, and a mixture of peptides Pro-Gly+Gly-Pro to rats for 5 days enhanced anticoagulant and fibrinolytic potential of the plasma (total fibrinolytic activity and plasmin and plasminogen activator activities) and decreased antiplasmin concentration. Semax and Pro-Gly-Pro decreased the weight of thrombi during experimental thrombosis.

Authors

Cherkasova, K A; Lyapina, L A; Ashmarin, I P