Effects of Semax on the Default Mode Network of the Brain.

Bulletin of experimental biology and medicine2018PMID: 30225715

View on PubMed DOI: 10.1007/s10517-018-4234-3

Plain Language Summary

Brain imaging (resting-state fMRI) was used to measure how Semax affects the brain's default mode network — the set of regions active during rest and self-referential thought — in healthy volunteers. People who received Semax intranasally showed a larger volume of activity in the frontal portion of the default mode network compared to placebo, both 5 and 20 minutes after dosing. This is one of the first direct brain imaging studies of Semax, confirming that it produces measurable changes in neural network activity in healthy humans.

Abstract

The effects of nootropic drug Semax on the neuronal network of the brain were studied by the resting state functional magnetic-resonance imaging (resting state fMRI). The study was carried out on two groups of healthy volunteers (11 men and 13 women aged 43.9±9.5 years). Resting state fMRI was carried out 3 times: directly before and 5 and 20 min after intranasal 1% Semax (14 subjects) or placebo (10 subjects). The topography of the resting state default mode network was studied. A greater volume of the default mode network rostral (medial frontal cortex) subcomponent was detected in the Semax group in comparison with controls. Resting state fMRI confirmed Semax effects on the neuronal network of the brain and demonstrated topography of these effects.

Authors

Lebedeva, I S; Panikratova, Ya R; Sokolov, O Yu; Kupriyanov, D A; Rumshiskaya, A D; Kost, N V; Myasoedov, N F

Keywords

Semaxbraindefault mode networkresting state functional magnetic-resonance imaging